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Open Source Glucose Monitoring an the Front Lines of Innovation

Cloud-based CGM

[John] is the parent of a diabetic child, and his efforts to expand the communication options for his son’s CGM (continuous glucose monitor) have grown into a larger movement: #wearenotwaiting.

After receiving a new monitor—a Dexcom G4—[John] set about decoding its communication protocols. The first steps were relatively simple, using a laptop to snag the data from the CGM and storing it on a Google doc which he could access as the day went along. The next step involved connecting the monitor and a cellphone for around-the-clock data gathering. [John] managed to develop an Android app to accomplish just that, and shortly after people began to take notice. Both [Howard Look], the CEO of Tidepool, and [Lane Desborough], Chief Engineer of Medtronic, have thrown in their support, leading to further developments such as Nightscout, an open source solution for storing CGM data in the cloud.

This project is a victory not only for those with diabetes, but also for the open source community. [John] admits his initial hesitation for developing for the medical device platform: litigation from a corporation could cause devastation for him and his family despite his intentions to merely improve his son’s and others’ quality of life. Those fears have mostly subsided, however, because the project now belongs to both no one and to everyone. It’s community-owned through an open source repository. Check out the overview of [John's] work for more pictures and links to different parts of the #wearenotwaiting community.


Filed under: Medical hacks

Lego Drawing Machine Draws Block Shapes Best

Lego-drawing machine

Loving to draw but deathly afraid of pen ink, [Marcel] came up with a little drawing machine made out of Lego that will do it for him. It’s not a very complicated build but it does have several different components arranged such to complete a task, and that in itself is cool. Oh yeah, just kidding about the “afraid of pen ink” thing.

RC Car Servos are used to drive the pen in the X and Y directions. These servos only have a 180 degree range of motion which is not enough to move the pen very far. To increase the pen’s travel distance, [Marcel] attached a large gear to the servo which rotates a much smaller gear that rides on a rack gear attached to the bed. A Lego hinge takes the place of a Z axis and is used to set the height of the pen that is strapped to the machine via rubber band.

In order to make the machine draw, the user moves an analog joystick. The changing resistance values of the joystick’s potentiometers are measured by an Arduino. The Arduino then moves each servo to the appropriate position using PWM. If you’d like to know how to do this, check out the Knob Tutorial.

If you’re not ready to l’eggo your Lego drawing machines, check out this super complicated creation or this arm emulator that draws the Mona Lisa.

 


Filed under: Arduino Hacks

Role of mTOR Pathway as a Marker of Risk in Alzheimer’s Disease to Be Presented at AAIC 2014

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Role of mTOR Pathway as a Marker of Risk in Alzheimer's Disease to Be Presented at AAIC 2014

Check out our press release hub, powered by Business Wire. It's a one stop shop for industry announcements to help you stay on top of the latest technology and investment trends. Get the scoop here.

Development of Cytox’s novel blood-based mTOR assay highlighted at Copenhagen, DK meeting

MANCHESTER, England–(BUSINESS WIRE)–July 14, 2014–

Cytox, a leading developer of assays for risk assessment and prediction of dementia, announced the timing of a presentation discussing the development of a novel proprietary blood-based assay for the assessment of risk of cognitive decline.

The talk, entitled “The evaluation of mTOR pathway dysregulation as a novel blood-based phenotypic risk biomarker for the assessment of Alzheimer’s Disease and dementia” will be given on Thursday 17 July, between 08.30 and 10.00am, during the AAIC Symposia and Featured Research Sessions at the Bella Centre, A/S Convention Center, Copenhagen, by Professor Harald Hampel of Université Pierre et Marie Curie (Sorbonne), Paris, France.

More information about the event and Professor Hampel’s presentation can be found on the AAIC Conference website at http://bit.ly/1sGQyPh

The presentation refers to two on-going clinical studies in which blood samples are being collected from patients in Europe and in the United States. One study will examine mTOR dysregulation in well-characterized patients who have been diagnosed with probable Alzheimer’s Disease, Fronto-temporal Lobe Dementia (FTLD) or Dementia with Lewy bodies (DLB) against cognitively normal control groups.

A second study will evaluate the performance of the assay platform in patients with mild cognitive impairment (MCI) assessing the relationship between the assay output (mTOR dysregulation) and the presence or absence of amyloid plaques in the brain, a pathological hallmark of Alzheimer’s Disease, using Positron Emission Tomography (PET) imaging.

About Cytox Limited

Cytox Limited is a UK company researching into the role of mTOR pathway dysfunction and the associated development of prognostic tests for cognitive decline and risk of developing AD or other dementias. Cytox has exclusive rights to build on the discoveries made by the company’s scientific founder, Dr. Zsuzsanna Nagy of cell cycle-related biomarkers associated with the risk of developing dementia. The company is developing her work and assessing its significance in trials and will be looking to work with pharmaceutical partners to develop our understanding of the technology and its role in drug development.

For more about the mTOR pathway and its potential role in early identification of risk of Dementia and Alzheimer’s disease, follow this link: www.cytoxgroup.com/information-for-editors

Cytox Limited
Richard Pither, CEO,
+44 (1865) 338018
Richard.pither@cytoxgroup.com
www.cytoxgroup.com


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What Silicon Valley refuses to learn from Steve Jobs

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What Silicon Valley refuses to learn from Steve Jobs

Just about every tech leader in Silicon Valley says they admire Steve Jobs, but when it comes to following his lead, where's the love?

Visit any hacker hangout, tech firm, or investment company in Silicon Valley, and you're sure to hear people say how much they admire Steve Jobs. They'll say that he was the most effective CEO, the best innovator, the strongest motivator, the most ruthless negotiator, and the person with the clearest vision in the valley of where tech is going. Sure, he stepped on people's toes, and sometimes was unfair to coworkers, but what counts is how successful he was, right?

I first met Steve in a humanities seminar at Reed College. We were discussing the Parthenon frieze, and Steve told me my opinion was full of shit. This seventeen-year-old with the shock of scruffy hair, who looked like he had been sleeping on a couch (which he probably was), told me that if I wanted to understand art, I needed to get out in the world. He was shaming me to reject received ideas and to think for myself, and he seemed willing to kick my ass to get me to do it.

It is this attitude that Jobs turned into a creed and brand at Apple, epitomized by the "To the crazy ones" commercial and the famous 1984 launch ad for the Macintosh. It is easy to admire and pay lip service to Steve Jobs' rebel image, but why do so few in the valley today follow Steve's lead, and why are his most important lessons largely ignored by the people who claim to admire him?

Lesson #1 — Creating great products requires patience

Steve was known to chasten product teams with instructions to chuck everything and start over. The cost was high to Apple, but the result was that Apple succeeded when others failed. Microsoft had tablet hardware and software years before Apple, but it took Apple’s iPad to make the category mainstream. Other companies may offer more features in their products, and release them sooner, but user satisfaction studies show that consumers often prefer Apple's solutions.

In an era when most follow the lean doctrine of releasing a product early, and letting the market dictate product direction, Steve spent time refining the product internally until he felt it was ready to release. That requires time that most companies don't want, or can't afford to invest. Steve's approach took vision—and yes, arrogance— to think he knew better than others, plus the willingness to look beyond the horizon and envision products that customers did not know they needed yet.

Lesson #2 —  Think big

What would Steve think of today’s timorous innovators creating the umpteenth find-your-friends app, social sharing site, or cloud storage solution? For every Elon Musk who makes tackling three big, crazy ideas before breakfast seem easy, there are thousands of others who come to the valley to launch any project that an investor will put money into, worthwhile or not. Steve dared to shake things up, and thinking small was not part of his character.

Lesson #3 — Focus on your strengths

Many admire how successfully Steve cut projects and saved Apple when he returned as interim CEO in 1997. Steve learned a few things while he was exiled from Apple, and when he returned he focused the company on what Apple was good at and would attract customers back to the company. That required knowing his own and his company's strengths and weaknesses, and understanding Apple's customers. Yet, we still see companies squander energy and resources in too many directions. They should revisit 1997 and learn from Steve's example.

Lesson #4 — Think different

When it comes to people per square mile trying to profit from others' success, Silicon Valley rivals the heydays of the California Gold Rush. You can't throw a USB flash drive in the Valley without hitting someone who wants to advise you, mentor you, teach you to code or pitch, or tighten up your growth hacking skills. Steve would tell you that listening to others is the route to mediocrity. You can't "think different" when you're taking your lead from the same people as everyone else.

Lesson #5 — Technology by itself is not enough

This is where we in Silicon Valley most fail Steve. Steve was a college dropout, but he valued learning and culture, and applied what he knew of music, calligraphy, design, and architecture to projects at Apple.

Today, young programmers and entrepreneurs in the valley are encouraged to drop out of college, or not pursue higher education at all, so they can focus all their attention on writing code or learning how to run a company. What value is Shakespeare, Beethoven, or Manet to someone who spends twenty hours a day on a computer? Apple's products are beautiful to many because they are not only useful, but strive for something transcendent in their design and concept. The products might not always achieve that, but the effort reminds people of their own dreams.

As Steve said at the iPad 2 launch in March of 2011, "It’s in Apple’s DNA that technology alone is not enough. It’s technology, married with liberal arts, married with the humanities, that yields us the result that makes our heart sing."

If Steve were around today, he'd kick our ass.

Rod Bauer is a principal of the Bauer Group, a consultancy that works with established and startup companies to develop and execute marketing strategies. 


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Hackers only need to get it right once; we need to get it right every time

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Hackers only need to get it right once; we need to get it right every time
Image Credit: Shutterstock

Hackers need to find one weak point to steal valuable information, while you must account for every possible vulnerability across your entire infrastructure. We must band together, think like a bad guy and take action to protect what matters.

Recent high visibility hacks, such as those at Target and Neiman Marcus, are powerful reminders that we need to outpace our adversaries and prepare for what might come. However, fighting crime is a losing battle if the adversary is two steps ahead of the law. How can we protect ourselves against faceless criminals motivated by large financial rewards?

Enter the Security Operations Center (SOC), a central control room detecting and responding to security breaches around the clock. A critical component of any security strategy, it's only as good as the people, processes, and technologies within it. This includes incorporating traditional IT operations, taking a converged approach to security that brings together existing IT monitoring practices with security operations, and providing a holistic view of risk across the enterprise.

A recent Ponemon Institute study revealed that companies investing in a comprehensive SOC achieved 20 percent better ROI on security spend and saved on average $4 million more than SOC-less peers.

Many organizations feel putting the basics in place is sufficient, but going through – or seeing peers go through – a high-profile, public breach involving negative publicity and lost revenue demonstrates the importance of a highly capable SOC. Industries with mature defense capabilities, such as large retailers and financial institutions, are not immune. They can be even bigger targets due to their volumes of valuable customer data.

In a recent five-year study on the state of nearly 70 global SOCs across private and public sector organizations, HP found 3 out of 4 organizations were unable to achieve basic consistency of operations, and only 30 percent of organizations that formally defined business goals and compliance requirements were able to meet them.

According to the study, having the right people in place can have the most profound impact on the overall capability of a SOC, but that's often overshadowed by an over-reliance on technology. Organizations invest more money in technology rather than staffing trained analysts to run these centers. Systems cannot apply non-linear thinking to an incomplete picture to develop a reasonable hypothesis. Human analytical capacity is still the most effective weapon in a company's security arsenal.

With a high demand for relevant security skills and a steady increase in compensation for experienced individuals, entities must invest in skills development and talent retention to sustain security operations. HP studied the effectiveness of a Fortune 100 company's SOC, finding the company's steady progression in the development of key SOC staff resulted in consistent processes and the right mix of expertise needed to operate effective security operations. Breaches and research continue to spotlight the lack of qualified security professionals in the information security industry.

Recent Ponemon Institute research highlighted that 40 percent of all security positions are unfulfilled today. Universities cannot rapidly produce graduates, and they struggle to provide sufficient real-world experience while security threats surge and organizations strive to strengthen their internal security defense teams. SOCs must prepare for this and develop hiring pipelines through relationships with local universities, ancillary teams across the company, and industry groups. Recognizing the market competitiveness of security skills and investing in talent will prevent attrition threatening security sustainability.

Cyber criminals will never stop learning and sharing information enabling them to attack high-profile targets and intellectual property. Hackers only have to get it right once. It's time for organizations do the same, investing in comprehensive SOCs by converging technology, processes, and people to protect what matters.

Chris Triolo, vice president of Professional Services, Education and Support, HP Enterprise Security Products. HP recently published a report on capabilities and maturity of cyber defense organizations, available at www.hp.com/go/StateOfSecOps.








Parallels Desktop 9.0.24237

Fixes a couple of issues related to the upcoming OS X Yosemite. ($79.99 new, free update, 361 MB)

 

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Skype 6.19

Adds Voice Over support for selecting recent searches of the Add Contacts field. (Free, 41.9 MB)

 

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Hackaday Links: July 13, 2014

hackaday-links-chain

Don’t like sunglasses? Deal with it. They’re the pixeley, retro sunglasses from your favorite animated .GIFs, made real in laser cut acrylic. Points of interest include heat-bent frames made out of a single piece of acrylic.

Remember this really small FPGA board? The kickstarter is ending really soon and they’re upgrading it (for an additional $30) with a much better FPGA.

Sparkfun is now hosting the Internet of Things. They’re giving people a tiny bit of space to push data to, and you can also deploy your own server. That’s interesting, and you can expect us doing a full post on this soon.

Need waveforms? [Datanoise] is building a wavetable synthesizer, and he’s put all his waveforms online. Now if we could just get a look at the synth…

If you only have $20 to spend on a board, you’ll want to pick up at Teensy 3.1. [Karl] wrote some bare metal libraries for this awesome board, and while it’s not as extensive as the standard Arduino libs, it’s more than enough to get most projects off the ground. Included are UARTs, string manipulation tools, support for the periodic interval timers on the chip, and FAT and SD card support.


Filed under: Featured, Hackaday links

ADC For Raspi Without Using An ADC

Schematic of ACD for a raspi

With all the amazing and wonderful things a Raspberry Pi can do, it is sorely lacking a dedicated ADC chip. Sure, you can wire up an ADC via SPI or even I2C with a little work, but still. It would be nice to have access to an Analog to Digital converter without having to go through the trouble. Fortunately, [Hussam] has figured out a way to do just this.

Using a comparator, two resistors, a single capacitor and a few lines of code, [Hussam] managed to get an active ADC working on his Raspberry Pi. He’s using the PWM1 and a passive RC filter to make a DAC. He then uses the comparator along with a ‘ successive approximation algorithm’ to complete the ADC.

[Hussam] mentions that the hack is not new, and this technique has been used before for microcrotrollers that lack a built-in ADC. But we are still impressed with his attention to detail in describing how to do this on a Raspi. Be sure to check out the link for full details, code, and an awesome description on how his algorithm works.


Filed under: Raspberry Pi

Introducing The Raspberry Pi B+

rpi-b-plus

Click to embiggen

It looks like Element 14 screwed up a single shipment, because some lucky soul just received an unreleased model of Raspberry Pi. If you can believe the silkscreen, it’s called the Raspberry Pi Model B+, and while we have no idea what the chipset is, the layout and peripherals look pretty cool.

From the looks of it, this new board features four USB ports, a new, 40-pin GPIO header, and more screw holes that will allow you to secure this to anything. The analog video out is gone, and the SD card connector – a weak point of the original design – might be replaced with a microSD connector. Oh, every Raspi case that has ever been made? They won’t work.

Without booting this Raspi B+ there’s no way of knowing what the chipset is on this new board. The smart money is on the entire SOC being the same: basically, what you’re looking at is the same as a Raspberry Pi Model B, only with a few more ports.

There is no clue when these improved Raspis will be available, but the word “soon™” will probably appear on the Raspberry Pi blog shortly.

Thanks [John] for the tip.

EDIT: [feuerrot] is smarter than me and mirrored all the images in an imgur album.

 


Filed under: Raspberry Pi

The history of Rap Genius: from rap lyrics blog to annotation powerhouse

The history of Rap Genius: from rap lyrics blog to annotation powerhouse

Above: Genius' logo, formerly known as Rap Genius


First Rap Genius helped the Web understand rap. Then the startup set out to annotate everything, from literature and history to sports and film.

Now with 40 million in new funding from Dan Gilbert and Andreessen Horowitz, Rap Genius has a new name: “Genius.”

Genius had no plans to expand beyond rap lyrics when it launched in 2009. To understand how the startup became the annotation powerhouse it is today, let’s once again take a trip down context lane.

Click on the dates below to learn more about each milestone.

 October 2009:  RapExegesis launches with a small team of less than ten people annotating rap lyrics. The site first debuted as a blog to explain the lyrics from Cam’ron’s “Purple Haze” album, according to the Wall Street Journal.

 December 2009:  RapExegesis rebrands as Rap Genius.

 June 2011:  Rap Genius joins the Y-Combinator startup accelerator, and is later dubbed “the fastest-growing Y Combinator company” of all time.

 August 25, 2011:  The startup raises a $1.8 million seed round from Betaworks.

 Mid 2011:  Rap Genius surpasses one million unique hits per month.

 October 3, 2012:  Andreessen Horowitz invests $15M in Rap Genius, with additional participation from Reddit cofounder Alexis Ohanian and AF Square. The company proclaims that its serious, academic take on rap lyrics will help elevate the genre to the level of poetry.

 June 25, 2013:  Rap Genius expands beyond rap lyrics, launches "News Genius," "Poetry Genius," and "Rock Genius."

August 19, 2013: The company surpasses 4.9 million unique visitors per month (comScore) and hits 25 employees.

 November 11, 2013:  Rap Genius is targeted by the National Music Publishers Association for not obtaining licenses to publish song lyrics.

 December 24, 2013:  The startup comes under fire from Google for using unscrupulous SEO methods to make sure it pops up as the first result in any lyric-related Google search.

 January 4, 2014:  Rap Genius apologizes to Google, and the lyrics site's pages return to search results.

 January 28, 2014:  The company launches its first app, "Genius," for iPhone — hinting at the company's future rebrand.

 May 26, 2014:  Rap Genius cofounder Mahbod Moghadam is forced out of the company over insensitive comments about the Santa Barbara shooting.

 July 11, 2014:  Rap Genius changes its name to "Genius," raises $40 million from Dan Gilbert and Andreessen Horowitz, and debuts embedded annotations service.

What's next for Genius? A 2018 IPO, according to one of its founders. Tells us what you think of the startup's new direction in the comments below.


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Andreessen Horowitz is a $950 million venture capital firm that was launched on July 6, 2009. Marc Andreessen and Ben Horowitz are the general partners of the firm.... read more »

Rap Genius is your guide to the meaning of rap lyrics. You can listen to songs, read their lyrics, and click the lines that interest you for pop-up explanations – we have thousands of canonical rap songs explained. Anyone can cre... read more »